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. Author manuscript; available in PMC: 2021 Oct 4.
Published in final edited form as: J Neurochem. 2020 Sep 30;156(3):309–323. doi: 10.1111/jnc.15180

FIGURE 6.

FIGURE 6

Levels of aggregate-prone proteins in ubiquitin-specific protease 14-deficient cortical neurons treated with IU1 or IU1-47. Quantitation and representative immunoblots of the levels of (a, b) TARDBP, (c, d) prion protein (PRNP), and (e, f) microtubule associate protein tau (MAPT) in cortical neurons from axJ mice treated with 10 μM or 50 μM of IU1 for 24 hr. Quantitation and representative immunoblots of the levels of (g, h) TARDBP, (i, j) PRNP, and (k, l) MAPT in cortical neurons from axJ mice treated with 10 μM or 50 μM of IU1-47 for 24 hr. Quantitations are shown relative to levels observed in neurons treated with DMSO alone (0 μM). β-tubulin was used as a loading control. Data are shown as mean ± SEM. n = 3 for IU1 treatment and n = 5 for IU1-47 treatment. *p < .05. **p < .01. ***p < .001. ****p < .0001