Table 2.
Univariate and multivariate analysis of prognostic factors in 75 LUAD patients
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Sex | ||||
| Female | 1.00 | 0.467 | ||
| Male | 0.828 (0.499-1.376) | |||
| Age (years) | 1.00 | 0.242 | ||
| <65 | 0.732 (0.435-1.234) | |||
| ≥65 | ||||
| Smoking | ||||
| No | 1.00 | 0.028* | 1.00 | 0.010* |
| Yes | 1.837 (1.070-3.155) | 2.085 (1.193-3.644) | ||
| Lymph node metastasis | ||||
| N0 | 1.00 | 0.214 | ||
| N1/N2/N3 | 1.384 (0.829-2.313) | |||
| Differentiation | ||||
| Well/moderate differentiation | 1.00 | 0.013* | 1.00 | 0.017* |
| Poor differentiation | 1.898 (1.142-3.155) | 1.902 (1.121-3.229) | ||
| Tumor size (cm) | ||||
| ≤5 | 1.00 | 0.776 | ||
| >5 | 0.922 (0.525-1.619) | |||
| TNM stage | ||||
| I/II | 1.00 | 0.062 | ||
| III/IV | 1.640 (0.976-2.757) | |||
| DDIT4 | ||||
| Low | 1.00 | 0.016* | 1.00 | 0.041* |
| High | 2.021 (1.137-3.590) | 1.853 (1.025-3.349) | ||
Statistical analyses were performed by Cox proportional hazards regression. P-values<0.05 were considered significant. CI, confidence interval.