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. 2021 Sep 9;12(21):6563–6575. doi: 10.7150/jca.62309

Figure 3.

Figure 3

Validation of 2 potential biomarkers from upregulated expression proteins. A) Hierarchical clustering analysis of 29 significantly up-regulated genes (FC>5, P<0.01) was performed on the Heml 1.0.3.7 derived from TCGA-KIRC datasets. The expression of 29 genes were consistent with our quantitative proteomic results. B) Kaplan-Meier curves for OS of patients with ccRCC were performed. Patients with ccRCC were divided into “high”and “low”groups based on median values of genes mRNA sequencing quantification data from TCGA-KIRC project. C) ROC curve analysis was performed to evaluate the specificity and sensitivity of the genes FMNL1 and CORO1A for differentiating ccRCC and paired normal tissues in the TCGA-KIRC datasets.