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Metformin counteracts angiotensin II (AngII)-induced blood pressure (BP) increase in mice. Effects of metformin on systolic BP (A) and diastolic BP (B) in AngII-infused (apolipoprotein E knockout [ApoE−/−]) mice (n = 8-12 in each group). Data presented as the mean ± standard deviation and analyzed using analysis of variance adjusted with the Fisher least significant difference test (∗P < .05).
