Table.
Altered genes (analyzed using whole transcriptome arrays) in mouse aortas from angiotensin II-infused mice treated with or without metformin
| Gene | FCa | P value |
|---|---|---|
| Ighv7-3 | −6.1 | .043 |
| Spp1 (osteopontin) | −4.1 | .001 |
| Atp6v0d2 | −4.0 | <.001 |
| Gpnmb | −4.0 | <.001 |
| Mmp12 | −3.1 | .004 |
| Alb | −2.9 | .034 |
| Clec7a | −2.8 | .008 |
| Mup20 | −2.7 | .034 |
| Ms4a7 | −2.6 | .026 |
| CD68 | −2.4 | .027 |
| Trem2 | −2.3 | <.001 |
| Col6a5 | −2.3 | .004 |
| Rnu1b1 | −2.2 | .015 |
| Mup-psp20 | −2.1 | .036 |
| Rnu1b1 | −2.1 | .020 |
| Rnu1b2 | −2.1 | .020 |
| Rnu1b6 | −2.0 | .024 |
| Hhip | 6.6 | .003 |
FC, Fold change.
a
FC in gene expression between metformin (n = 6) and no metformin (n = 8) mice treated with angiotensin II (P value computed using the Student t test); the results were not significant when adjusted using the false discovery rate.