Table 2.

Primary endopoint-related univariate and multivariate Cox regression analysis in entire study cohort.

	Univariate analysis			Multivariate analysis
	HR	95% CI	P value	HR	95% CI	P value
In-hospital death and/or respiratory support upgrade
Age	1.024	1.016–1.031	<0.001
Male gender	1.312	1.085–1.585	0.005	1.424	1.100–1.842	0.007
Hypertension	1.244	1.039–1.490	0.018
ASA	0.788	0.647–0.960	0.018	0.697	0.525–0.924	0.012
N/L > 3	1.549	1.239–1.938	<0.001	1.483	1.145–1.919	0.003
eGFR <60 mL/min/1.73m2	1.466	1.207–1.780	<0.001	1.351	1.054–1.731	0.018
Glucocorticoid	0.698	0.558–0.872	0.002	0.782	0.622–0.985	0.036
In-hospital death
Age	1.069	1.058–1.081	<0.001	1.066	1.047–1.085	<0.001
Hypertension	1.577	1.251–1.987	<0.001
Heart failure	1.728	1.275–2.342	<0.001
Previous ischemic stroke/TIA	1.619	1.008–2.601	0.046
Chronic obstructive pulmonary disease	1.411	1.069–1.862	0.015
N/L > 3	1.519	1.128–2.045	0.006	1.468	1.054–2.045	0.023
Hemoglobin	0.913	0.855–0.975	0.007
eGFR <60 mL/min/1.73m2	2.693	2.071–3.502	<0.001	1.728	1.263–2.365	0.001
Low-molecular weight heparin	0.640	0.477–0.858	0.003	0.660	0.487–0.893	0.007
Respiratory support upgrade
Male gender	2.084	1.473–2.949	<0.001	1.855	1.232–2.794	0.003
ASA	0.640	0.458–0.894	0.009	0.529	0.333–0.839	0.007
N/L > 3	1.706	1.211–2.404	0.002
Low-molecular weight heparin	1.652	1.154–2.364	0.006
Glucocorticoid	0.477	0.346–0.659	<0.001	0.556	0.395–0.782	0.001

ASA: acetylsalicylic acid. eGFR: estimated glomerular filtration rate. N/L: neutrophils to lymphocytes ratio. TIA: transient ischemic attack.

Data are presented as hazard ratio (HR) with 95% confidence interval (CI) and p values. Only covariates with a univariate statistical significance of <0.05 were reported.