Table 1: Impact of obesity on key human immune cell subsets.

Within AT, alterations are in VAT if not listed as SAT. Up arrows indicate enriched populations, down arrows indicate less prevalent populations and sideways arrow indicates no significant difference measured. AT = adipose tissue, PB = peripheral blood.

Cell type	Adult		Child
	AT	PB	AT	PB
B cells	→VAT p = 0.055 ↑SAT [60]	→[23,48] ↑[59]		↑Bnaive [53] →Bmemory [53]
Vaccine Responses	n/a	↓Hepatitis B [98–102] →Influenza [103–105] ↑PPSV23 [106]	n/a	↓Hepatitis B [107] ↓Tetanus [108] →Influenza [109,110]
CD4 T cells	↑[78]	↑[59,77] ↓[23] →[48,51,52,58,60]		→[72]
Naïve CD4 T cells		↑[77]↓[57] →[23]
Non-naïve CD4 T cells		↑[75,76] TEM, ↓[23] TMEM, ↑[77] TN, TCM, TEMRA
Th1 cells	→[92]	→[77]		→↑[53,72]
Th2 cells	→[92]	↑[77]		→[72]
Th17 cells	↑[92] in insulin resistant ptx
Th22 cells	↑[92] in insulin resistant ptx
Tregs	↓ [84]	→[51,60] ↑[77] ↓[75]		→[53]
CD8 T cells	↑[78]	↓[23] ↑[59] →[48]
Naïve CD8 T cells	→[77]
Non-naïve CD8 T cells	→[77]
NK cells	variable[69]	↓[59,67,68] →[47,48,57] ↑[60]		↓[71]
NKT cells	↓[52]	↓[47,50,52] →[48,49]		→[53]
Monocytes	n/a	→[48,57,58] ↑[59]		→[53] ↑[26]
Classical	n/a	↑[60]		↑[9] ↑[26]
Non-classical	n/a	↑[60]		↑[35]
Adipose Tissue Macrophages (ATM)	↑[134]	n/a
Pro-inflammatory (M1) (v. Anti-inflammatory (M2) ATM	↑[60,62]
CD9+ ATMs	↑[64,65]
Eosinophil	↑[41] in SAT
Neutrophil		↑[59]		↑[26]
Mast cell	↑[38,39]
MAIT cell	↓[51,54]	↓[51,54] →[49]		↑[54]