Table 3.

Pharmacokinetic parameters of CBD oil (100 mg/kg) and CBD-NE (50 mg/kg) administered orally to rats

Parameter	CBD oil (n = 4)	CBD-NE (n = 5)	p
Dose, mg/kg	100	50
AUC0–24, mg h/L	25.3±4.4	16.2±2.7
AUC0–24/dose, h kg/L	0.253±0.044	0.324±0.053	0.409
AUC0-∞, mg h/L	26.7±4.5	22.4±4.3
AUC0-∞/dose, h kg/L	0.272±0.045	0.448±0.087	0.172
T1/2, h	4.68±0.31	2.40±3.49	0.069
CLtot/F, L/h/kg	4.29±1.67	2.81±0.67	0.258
Vdss/F, L/kg	46.7±9.6	36.0±7.4	0.456
Tmax, h	8.00±0.00	2.40±0.46	<0.001***
Cmax, μg/mL	2.72±0.37	3.23±0.80
Cmax/dose, kg/L	0.0272±0.0037	0.0646±0.0159	0.103
MRT, h	10.8±0.4	15.10±3.7	0.356

Each value is expressed as mean ± SEM.

AUC, area under the concentration versus time curve; T_1/2, terminal half-life; CL_tot/F, total clearance; V_dss/F, volume of distribution; C_max, maximum blood concentration; T_max, time to reach C_max; MRT, mean residence time.

^***p < 0.001 versus CBD oil.