Table 4.
Pharmacokinetic parameters of CBD oil (50 mg/kg) and CBD-NE (50 mg/kg) administered orally to bile-fistulated rats
| Parameter | CBD oil (n = 3) | CBD-NE (n = 3) | p |
|---|---|---|---|
| Dose, mg/kg | 50 | 50 | |
| AUC0–10, mg h/L | 0.300±0.019 | 5.9±1.1 | 0.056 |
| AUC0–∞mg h/L | 0.502±0.127 | 10.8±0.1 | <0.001*** |
| T1/2, h | 5.46±1.81 | 8.3±2.2 | 0.461 |
| CLtot/F, L/h/kg | 117±23 | 4.62±0.05 | 0.059 |
| Vdss/F, L/kg | 992±21 | 63.3±16.0 | <0.001*** |
| Tmax, h | 4.00±0.00 | 4.00±0.00 | |
| Cmax, μg/mL | 0.0588±0.0015 | 0.90±0.20 | 0.077 |
| MRT, h | 10.0±2.6 | 13.7±3.4 | 0.520 |
Each value is expressed as mean ± SEM. For abbreviations, see Table 3.
***
p < 0.001 versus CBD oil.