Table 1.
Hepatically expressed cytochrome P450 enzymes
| Enzyme | Hepatic expression range, % of total | Dronabinol | Nabilone | CBD | Nabiximols |
|---|---|---|---|---|---|
| CYP3A4 | 14.5–37.0 | √ | √ | √ | √ |
| CYP2C8 | ~7.5 | √ | √ | √ | |
| CYP2E1 | 5.5–16.5 | √ | √ | √ | √ |
| CYP2C9 | 4.5–29.0 | √ | |||
| CYP1A2 | 4.4–16.3 | √ | √ | ||
| CYP2A6 | 3.5–14.0 | √ | √ | ||
| CYP2B6 | 1.7–5.3 | ||||
| CYP2D6 | 1.3–4.3 | ||||
| CYP2C19 | 0.9–3.8 | √ | √ | ||
| CYP2J2 | <1.0 | √ | √ | √ | |
| CYP1A1 | <1.0 | ||||
| CYP1B1 | 0.0 | ||||
| CYP3A5 | ~1.0 |
The 3 primary cytochrome P450 enzymes (CYP3A4, CYP2C9, and CYP2C19) involved in cannabinoid metabolism are highlighted in bold. CBD, cannabidiol.