Table 2.
List of Narrow Therapeutic Index (NTI) medications to be closely monitored when coadministered with cannabinoids, either therapeutically or recreationally
| Narrow Therapeutic Index (NTI) medication | Enzyme/metabolism |
|---|---|
| acenocoumarol (VKA) | CYP1A2, CYP2C9, CYP2C19, CYP3A4 |
| alfentanil | CYP3A, CYP3A4 |
| aminophylline | CYP1A2, CYP3A4 |
| amiodarone | CYP1A2, CYP2C8, CYP2C19, CYP3A4 |
| amitriptyline | CYP1A2, CYP2B6, CYP2C19, CYP3A4 |
| amphotericin B | Protein binding |
| argatroban | CYP3A4 |
| busulfan | CYP3A4 |
| carbamazepine | CYP1A2, CYP3A4, UGT2B7 |
| clindamycin | CYP3A4 |
| clomipramine | CYP1A2, CYP2B6, CYP2C19, CYP3A4, UGT2B7 |
| clonidine | CYP1A2, CYP3A4 |
| clorindione (VKA) | CYP3A4 |
| cyclobenzaprine | CYP1A2, CYP3A4 |
| cyclosporine | CYP3A4 |
| dabigatran etexilate | UGT1A9, UGT2B7 |
| desipramine | CYP1A2, CYP2B6 |
| dicoumarol (VKA) | CYP2C9 |
| digitoxin | CYP3A4 |
| dihydroergotamine | CYP3A4 |
| diphenadione (VKA) | CYP3A4 |
| dofetilide | CYP3A4 |
| dosulepin | CYP2B6 |
| doxepin | CYP1A2, CYP2C9, CYP2C19, CYP3A4 |
| ergotamine | CYP3A4 |
| esketamine | CYP2B6, CYP3A4 |
| ethinyl estradiol (oral contraceptives) | UGT1A9, UGT2B7 |
| ethosuximide | CYP2E1, CYP3A4 |
| ethyl biscoumacetate (VKA) | CYP3A4 |
| everolimus | CYP3A, CYP3A4 |
| fentanyl | CYP3A4 |
| fluindione (VKA) | CYP2C9, CYP3A4 |
| fosphenytoin | CYP2C8, CYP2C9, CYP2C19, CYP3A4 |
| imipramine | CYP1A2, CYP2B6, CYP2C19, CYP3A4 |
| levothyroxine | CYP3A4 |
| lofepramine | CYP2B6 |
| melitracen | CYP2B6 |
| meperidine | CYP2B6, CYP3A4 |
| mephenytoin | CYP1A2, CYP2C19 |
| mycophenolic acid | UGT1A9, UGT2B7 |
| nortriptyline | CYP1A2, CYP2B6, CYP3A4 |
| paclitaxel | CYP2C8, CYP3A4 |
| phenobarbital | CYP2C19 |
| phenprocoumon (VKA) | CYP2C8, CYP2C9, CYP3A4 |
| phenytoin | CYP2C8, CYP2C9, CYP2C19 |
| pimozide | CYP1A2, CYP3A, CYP3A4 |
| propofol | UGT1A9 |
| quinidine | CYP2C9, CYP2E1, CYP3A4 |
| sirolimus | CYP3A, CYP3A4 |
| tacrolimus | CYP3A, CYP3A4 |
| temsirolimus | CYP3A4 |
| theophylline | CYP1A2, CYP3A4 |
| thiopental | CYP2C19 |
| tianeptine | CYP3A4 |
| trimipramine | CYP2B6 |
| valproic acid | CYP2C9, UGT1A9, UGT2B7 |
| warfarin (VKA) | CYP1A2, CYP2C9, CYP2C19, CYP3A4 |
VKA, vitamin K antagonist.