Table 2.

Hazard Models of Non-Exercise Estimated Cardiorespiratory Fitness in the NIH-AARP Diet and Health Study of Men Participants (n=186,469).

Group/CRF Categories	Total	VO2 max Q-1 (<31.5 mL•kg−1•min−1) (n=46,934)	VO2 max Q-2 (31.5-35 mL•kg−1•min−1) (n=47,133)	VO2 max Q-3 (>35-38.2 mL•kg−1•min−1) (n=45,537)	VO2 max Q-4 (>38.2 mL•kg−1•min−1) (n=46,865)	P trend	1-mL•kg−1•min−1 increase	P value
All-cause mortality (n/%)	34,317 (18.4)	12,976 (27.6)	9,250 (19.6)	6,965 (15.3)	5,126 (10.9)	<0.001	<0.001	<0.001
HR 95% (CI)		1 (Reference)	0.82 (0.79-0.84)	0.74 (0.72-0.77)	0.7 (0.67-0.73)	<0.001	0.96 (0.95-0.96)
Cardiovascular disease mortality (n/%)	5,262 (2.8)	2,283 (4.9)	1,397 (3)	952 (2.1)	630 (1.3)	<0.001	<0.001	<0.001
HR 95% (CI)		1 (Reference)	0.81 (0.75-0.87)	0.72 (0.66-0.79)	0.69 (0.61-0.77)	<0.001	0.95 (0.94-0.96)
Cancer mortality (n/%)	12,629 (6.8)	4,281 (9.1)	3,431 (7.3)	2,779 (6.1)	2,138 (4.6)	<0.001	<0.001	<0.001
HR 95% (CI)		1 (Reference)	0.84 (0.8-0.89)	0.79 (0.74-0.83)	0.71 (0.66-0.76)	<0.001	0.97 (0.96-0.97)

CI; confidence intervals, HR; hazard ratio, MET; metabolic equivalent. N/A; not applicable. Q-quartile. Risk models were adjusted for race ethnicity, marital status, education level, age, body mass index, first-degree relatives with history of cancer, diabetes, hypertension, dyslipidemia, smoking status, total alcohol drinks per day, total energy intake, fibers intake, fruits intake, vegetables intake and red meat intake.