Table 3.

Hazard Models of Non-Exercise Estimated Cardiorespiratory Fitness in the NIH-AARP Diet and Health Study of Women Participants (n=144,300).

Group/CRF Categories	Total	VO2 max Q-1 (<21.8 mL•kg−1•min−1) (n=36,292)	VO2 max Q-2 (21.8-25.7 mL•kg−1•min−1) (n=36,384)	VO2 max Q-3 (>25.7-29.2 mL•kg−1•min−1) (n=35,314)	VO2 max Q-4 (>29.2 mL•kg−1•min−1) (n=36,310)	P trend	1- mL•kg−1•min−1 increase	P value
All-cause mortality (n/%)	20,295 (14.1)	7,676 (21.2)	5,479 (15.1)	4,182 (11.8)	2,958 (8.1)	<0.001	<0.001	<0.001
HR 95% (CI)		1 (Reference)	0.84 (0.81-0.88)	0.78 (0.75-0.82)	0.72 (0.68-0.77)	<0.001	0.95 (0.94-0.96)
Cardiovascular disease mortality (n/%)	3,371 (2.3)	1,503 (4.1)	919 (2.5)	606 (1.7)	341 (0.9)	<0.001	<0.001	<0.001
HR 95% (CI)		1 (Reference)	0.84 (0.77-0.93)	0.75 (0.66-0.84)	0.63 (0.54-0.73)	<0.001	0.95 (0.94-0.96)
Cancer mortality (n/%)	7,548 (5.2)	2,411 (6.6)	2,047 (5.6)	1,698 (4.8)	1,392 (3.8)	<0.001	<0.001	<0.001
HR 95% (CI)		1 (Reference)	0.88 (0.82-0.94)	0.82 (0.76-0.89)	0.77 (0.7-0.85)	<0.001	0.97 (0.96-0.98)

CI; confidence intervals, HR; hazard ratio, MET; metabolic equivalent. N/A; not applicable. Q-quartile. Risk models were adjusted for race ethnicity, marital status, education level, age, body mass index, first-degree relatives with history of cancer, diabetes, hypertension, dyslipidemia, smoking status, total alcohol drinks per day, total energy intake, fibers intake, fruits intake, vegetables intake, red meat intake and menopausal status.