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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Auton Neurosci. 2021 Aug 2;235:102861. doi: 10.1016/j.autneu.2021.102861

Fig.10.

Fig.10

The model of intraspinal EUS- neural circuit which can support tonic and bursting activity depending of strength of synaptic connections and the power of input afferentation. Excitatory synaptic connections are depicted by arrows and inhibitory connections by T-like endings; thickness of lines corresponds to the power of afferentation. A – Full SI circuit has a strong input from the PMC. B – Immediately after SCI the excitatory input to EUS-MNs weakens, feedback inhibition is inactivated (dashed brown lines) and detrusor-sphincter-dyssynergia develops. C – Upon recovery, afferent activity from the bladder (BL) is increased due to increased excitability of C-fiber afferents. Bolder symbols for PPSN in LSCC, IN1 and IN2 in DCM designate sprouting and involvement of additional neurons in the circuit. IN1, IN2 and PPSN can generate stronger outputs due to intra- and inter-segmental sprouting. This may be sufficient for re-activation of MN2 and InhN, which will restore EUS bursting.