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. 2021 Sep 10;12:737552. doi: 10.3389/fphar.2021.737552

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Copyright © 2021 Zheng, Zhou, Huang, Lai, Ji and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of miR-27a mimic-transfection on mechanical stimulation-induced MMP-13 expression were investigated. The expression of miR-27a (A) and GAS5 (B) was determined by qRT-PCR in miR-27a mimic-transfected chondrocytes. The mRNA (C) expression of MMP-13 was determined by qRT-PCR, and the protein expression of MMP-13 (D-E) and Col2a1 (D and F) were determined by western botting assays. (G) The immunofluorescence intensity of MMP-13 was detected. (H) The calculation of fluorescence activity of MMP-13. ^* p < 0.05 and **p < 0.01.