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. 2021 Sep 20;12:722730. doi: 10.3389/fphar.2021.722730

FIGURE 5.

FIGURE 5

SHCGT changed the gut microbiome in mice with DNCB-induced AD. (A) Taxonomic composition of the microbial community in the gut at the phylum level. (B) The increased relative abundance of Deferribacteres was attenuated by SHCGT in mice with AD. (C) Alpha diversity using the Shannon index score at the species level. No significant differences were observed. (D) A three-dimensional score plot based on principal coordinates analysis of weighted UniFrac distances showing different microbiome patterns in each group. (E) Top 25 species detected in pattern search analysis. The red letters indicate the gut microbiota components also detected by LEfSe analysis. (F) A significantly altered gut microbiota profile was identified by a combination of pattern search analysis, LEfSe, and univariate analysis. *p < 0.05 vs. sham; # p < 0.05, ## p < 0.01 vs. AD. AD, atopic dermatitis; DNCB, 2,4-dinitrochlorobenzene; LEfSe, linear discriminant analysis effect size; SHCGT, Sihocheonggan-Tang.