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. 2021 Jun 21;30(10):1565–1576. doi: 10.1177/09612033211025636

Table 2.

Results: prevalence of neuro-psychiatric manifestations of SLE in relevant studies identified by literature search.

Author, year (Cohort-name) Number of patients Prevalence NPSLE patients NPSLE patients NPSLE events CNS events PNS events
CNS
PNS
Aseptic meningitis Cerebrovascular disease Demyelinating syndrome Headache Movement disorder Myelopathy Seizure disorders Acute confusional state Anxiety disorder Cognitive disfunction Mood disorder Psychosis Guillain-Barré-Syndrome Autonomic disorder Mononeuropathy Myasthenia gravis Neuropathy cranial Plexopathy Polyneuropathy Included in meta-analysis
Abdel-Nasser, 2008 32 0.813 26 57 57 0 0 1 0 15 0 0 4 2 3 12 19 1 0 0 0 0 0 0 0 +
Abdul-Sattar, 2013 84 0.429 36 53 47 6 0 6 0 10 0 0 3 0 7 1 16 4 0 0 2 0 0 0 4 +
Ahn, 2018 1121 0.383 429 652 586 66 16 47 2 258 7 3 71 19 36 12 89 26 1 1 22 0 14 0 28 +
Ainiala, 2001 46 0.913 42 122 105 17 1 7 1 25 1 0 4 3 6 37 20 0 0 0 0 1 3 0 13 +
Alfetra, 2003 61 0.721 44 103 90 13 0 15 0 13 0 2 7 0 4 32 17 0 0 2 0 0 3 0 8 +
Appenzeller, 2005 115 0.626 72 133 126 7 1 0 0 40 1 3 15 10 0 36 14 6 0 0 4 0 3 0 0 +
Brey, 2002 128 0.797 102 290 259 31 0 2 0 73 1 0 21 0 27 67 62 6 0 0 9 0 2 0 20 +
Briani, 2009 219 0.388 85 96 64 32 0 11 0 35 0 2 10 0 0 0 0 6 0 0 15 0 0 0 17 +
Hanly, 2009 209 0.632 132 299 277 22 1 17 6 96 1 1 20 11 24 25 70 5 0 0 3 2 10 1 6 +
Hanly, 2011 1206 0.403 486 843 785 58 6 40 3 397 6 10 63 22 42 43 139 14 2 2 18 0 15 1 20 +
Kakati, 2017 52 0.365 19 53 43 10 1 0 0 5 1 0 8 6 2 11 5 4 0 2 1 0 3 0 4 +
Kampylafka, 2013 370 n.a. n.a. 23 21 2 1 6 0 0 0 5 8 0 0 0 0 1 n.a. n.a. n.a. n.a. 2a n.a. n.a. −
Katsumata, 2010 191 n.a. n.a. 72 72  n.a. 5 1 5 5 0 2 18 24 1 0 9 2 n.a. n.a. n.a. n.a. n.a. n.a. n.a. −
Magro-Checa, 2017 304 0.964 293 437 410 27 2 65 1 79 8 11 27 9 22 72 88 26 0 1 1 1 6 2 16 +
Mok, 2006 282 0.23 65 115 105 10 1 23 0 8 2 6 17 10 3 10 10 15 0 0 1 2 7 0 0 +
Morrison, 2014 108 0.63 68 126b 107b 18b 1 10 2 23 1 2 7 7 6 12 29 7 0 0 4 0 10 1 3 +
Muhammed, 2018 101 0.327 33 42 30 12 0 0 0 10 1 0 4 2 5 4 4 0 0 2 1 0 0 0 9 +
Pradhan, 2015 120 n.a. 60 170 168 2 0 12 0 24 0 1 35 0 11 22 18 45 0 0 0 0 2 0 0 −
Sanna, 2003 323 0.573 185 351 324 27 0 57 3 78 4 4 27 13 24 35 54 25 2 0 6 5 5 0 9 +
Schenatto, 2006 87 0.264 23 23 17 6 0 3 0 0 1 0 1 0 0 3 0 9 0 0 1 0 4 0 1 +
Sibbitt, 2002 75 0.947 71 258 246 12 1 9 3 54 5 1 38 26 16 41 43 9 0 0 0 0 1 0 11 +
vdMeulen, 2017 272 0.254 69 134 122 12 0 41 1 10 2 2 10 3 4 30 13 6 0 1 1 0 1 0 9 +
Zavada, 2013 471 0.106 50 102 93 9 2 13 0 13 1 1 11 2 3 25 14 8 0 0 2 0 3 0 4 +
Zirkzee, 2012 71 0.648 46 79 77 2 0 14 0 15 1 1 6 0 1 22 13 4 0 0 1 0 0 0 1 +
Meier, 2020 688 0.281 193 295 235 60 4 49 0 51 2 7 37 11 0 10 19 45 3 0 5 2 18 7 25 +

PNS: peripheral nervous system; CNS: central nervous system; n.a.: not applicable.

aAccording to ACR definition cranial neuropathy is a peripheral manifestation.

bOne event was not specified.