Table 3.
Multivariate analyses on overall survival in colon cancer (with the combination of less than four lymph nodes and less than eight lymph nodes retrieved together).
| Characteristics | Overall survival | ||
|---|---|---|---|
| HR (95% CI) | SE | p-value | |
| Race | <0.001 | ||
| White | Reference | ||
| Black | 1.195 (1.161–1.231) | 0.015 | <0.001 |
| Other | 0.780 (0.750–0.812) | 0.020 | <0.001 |
| Age at diagnosis | <0.001 | ||
| ≤75 years | Reference | ||
| >75 years | 2.524 (2.474–2.575) | 0.010 | |
| Histology | 0.005 | ||
| Adenocarcinoma | Reference | ||
| Mucinous/signet ring cell | 1.041 (1.012–1.072) | 0.015 | |
| T stage | <0.001 | ||
| T3 | Reference | ||
| T4 | 1.651 (1.612–1.690) | 0.012 | |
| N stage | <0.001 | ||
| N0 stage (<8 lymph nodes) | Reference | ||
| N0 stage (<12 lymph nodes) | 0.798 (0.764–0.833) | 0.022 | <0.001 |
| N0 stage (≥12 lymph nodes) | 0.626 (0.605–0.648) | 0.018 | <0.001 |
| N1 stage | 1.051 (1.014–1.090) | 0.018 | 0.006 |
| N2 stage | 1.606 (1.545–1.669) | 0.020 | <0.001 |
| Tumor grade | <0.001 | ||
| High/Moderate | Reference | ||
| Poor/Anaplastic | 1.146 (1.122–1.172) | 0.011 | <0.001 |
| Unknown | 1.136 (1.064–1.213) | 0.033 | <0.001 |
| Sex | <0.001 | ||
| Male | Reference | ||
| Female | 0.839 (0.824–0.855) | 0.010 | |
| Year of diagnosis | 0.508 | ||
| 2004–2007 | Reference | ||
| 2008–2010 | 1.007 (0.987–1.027) | 0.010 | |
| Chemotherapy | <0.001 | ||
| No | Reference | ||
| Yes | 0.586 (0.572–0.600) | 0.012 | |