Table 3.
Multivariable GEE Logistic Regression Models with Cleavage Stage Embryo Cell Count.
| Variables | Blastulation | Blastocyst Biopsied | Euploid | |||
|---|---|---|---|---|---|---|
| Adj. OR (95% CI)* | p-value | Adj. OR (95% CI)* | p-value | Adj. OR (95% CI)* | p-value | |
| Adjusted Day 3 Cell Count | 1.29 (1.27, 1.32) | <0.0001 | 1.24 (1.22, 1.26) | <0.0001 | 1.02 (1.01, 1.04) | 0.007 |
| Fragmentation Percent Low (<10%) Moderate (10-20%) High (>20%) |
Reference 0.39 (0.37, 0.42) 0.15 (0.13, 0.18) |
<0.0001 | Reference 0.38 (0.35, 0.41) 0.10 (0.07, 0.13) |
<0.0001 | Reference 1.05 (0.93, 1.18) 2.09 (1.26, 3.44) |
0.01 |
| Patient Age Group A (< 35) B (35-37) C (38-40) D (41-42) E (>42) |
Reference 1.01 (0.91, 1.13) 0.84 (0.76, 0.94) 0.65 (0.57, 0.75) 0.54 (0.49, 0.60) |
<0.0001 | Reference 0.95 (0.87, 1.04) 0.71 (0.64, 0.77) 0.44 (0.39, 0.50) 0.31 (0.28, 0.34) |
<0.0001 | Reference 0.79 (0.72, 0.87) 0.49 (0.44, 0.54) 0.25 (0.21, 0.30) 0.15 (0.13, 0.18) |
<0.0001 |
| BMI | 1.00 (0.99, 1.01) | 0.55 | 0.99 (0.98, 1.00) | 0.03 | 1.01 (1.00, 1.02) | 0.12 |
| AMH | 1.06 (1.01, 1.11) | 0.03 | 0.96 (0.91, 1.00) | 0.09 | 1.05 (1.00, 1.10) | 0.02 |
*
Adjusted analyses were performed using a multivariable logistic generalized estimation equation (GEE) modeling embryo cell division speed at day 3 accounting for within-correlation at the patient and cycle level, controlling for patient age, BMI, AMH, and percent embryo fragmentation.