Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Without dosage compensation, the transcriptional output of each cell is 0.5 for individual chromosomes, and one for chromosome pairs. X-chromosome upregulation (XCU) doubles each X-chromosome’s output (shown in red). X-chromosome inactivation (XCI) silences output of one X in females (shown in blue).
| No compensation | XCU | XCI | |
|---|---|---|---|
| female | AA = 1XX = 1 | AA = 1 XX = 2 |
AA = 1XX = 1 |
| male | AA = 1XY = 0.5 | AA = 1XY = 1 | AA = 1XY = 1 |
