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Schematic model for regulation of the nuclear receptor activity by the CLDN–adhesion signaling. The schema is modified from that reported previously (Sugimoto et al., 2019). SH2/3: Src homology 2/3 domain; Kinase: kinase domain; AF1: activation function-1; DBD: DNA-binding domain; LBD: ligand-binding domain; RARE: retinoic acid response element; ERE: estrogen response element; RA: yellow circle; estrogen: pink circle
