Table III.
Adjusted ORs for refill within 90 days after discharge and for initial fill
| Outcome: Refill | Outcome: Initial fill | |||
|---|---|---|---|---|
|
|
|
|||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Cost-sharing (ref: No LIS, no premium or copay subsidy) | ||||
| LIS with full subsidy | 1.39 (1.19–1.69) | < .001 | 1.29 (1.10–1.51) | .002 |
| LIS with partial subsidy | 1.18 (0.88–1.55) | .282 | 0.98 (0.74–1.30) | .896 |
| Preoperative opioid use (ref: Naïve) | ||||
| Intermittent | 1.93 (1.79–2.08) | < .001 | 1.10 (1.01–1.20) | .023 |
| Chronic | 11.93 (10.30–13.83) | < .001 | 1.34 (1.19–1.51) | < .001 |
| Surgery Type (ref: Hip replacement) | ||||
| Knee replacement | 3.39 (3.12–3.72) | < .001 | 1.30 (1.18–1.43) | < .001 |
| Spine surgery | 1.33 (1.15–1.54) | < .001 | 0.90 (0.77–1.05) | .169 |
| Shoulder surgery | 1.10 (0.95–1.27) | .205 | 1.14 (0.97–1.35) | .110 |
| Initial opioid prescription size* | 1.01 (1.00–1.01) | .009 | ||
| Age (Ref: 65–69) | ||||
| 70–74 | 0.88 (0.81–0.96) | .003 | 0.85 (0.77–0.94) | .001 |
| 75–79 | 0.74 (0.68–0.82) | < .001 | 0.76 (0.68–0.84) | < .001 |
| 80–84 | 0.66 (0.58–0.75) | < .001 | 0.57 (0.50–0.65) | < .001 |
| 85+ | 0.52 (0.43–0.64) | < .001 | 0.54 (0.44–0.66) | < .001 |
| Race (Ref: White) | ||||
| Black | 1.31 (1.08–1.58) | .006 | 0.82 (0.68–0.98) | .033 |
| Others | 0.88 (0.70–1.10) | .251 | 0.90 (0.71–1.14) | .384 |
| Unknown | 0.94 (0.66–1.32) | .707 | 1.09 (0.71–1.65) | .702 |
| Sex (ref: Male) | ||||
| Female | 1.26 (1.17–1.35) | < .001 | 1.08 (1.00–1.17) | .055 |
| Charlson comorbidity index (ref: CCI = 0) | ||||
| 1–2 | 1.04 (0.97–1.13) | .261 | 1.01 (0.93–1.10) | .749 |
| 3–4 | 1.01 (0.90–1.15) | .823 | 0.91 (0.80–1.03) | .141 |
| 5+ | 0.87 (0.72–1.05) | .147 | 0.86 (0.71–1.04) | .121 |
| Tobacco use (ref: Not use) | 1.10 (0.99–1.22) | .080 | 0.94 (0.84–1.04) | .235 |
| Mental health disorder | ||||
| Anxiety | 1.22 (1.04–1.44) | .018 | ||
| Depression | 1.15 (0.99–1.33) | .072 | ||
| Adjustment disorder | 1.50 (0.76–2.94) | .238 | ||
| Disruptive disorder | 0.42 (0.19–0.93) | .032 | ||
| Personality disorder | 0.40 (0.10–1.56) | .187 | ||
| Psychosis | 0.68 (0.37–1.27) | .225 | 0.70 (0.39–1.24) | .217 |
| Other mental health disorder | 1.39 (0.84–2.30) | .194 | ||
| Pain disorder | ||||
| Arthritis pain | 0.92 (0.84–1.01) | .083 | 0.92 (0.83–1.02) | .123 |
| Back pain | 1.07 (0.97–1.17) | .177 | ||
| Neck pain | 0.82 (0.72–0.93) | .002 | 0.85 (0.74–0.96) | .012 |
| Other pain | 1.11 (1.00–1.23) | .057 | 0.94 (0.84–1.05) | .276 |
CCI, Charlson comorbidity index.
*
In 10 tablets of 5 mg oxycodone; including prescriptions filled between 14 d.