Table 3.
Associations of NREM and REM IFL with SBP and DBP
| % Change in SBP (95% CI)* | P value | % Change in DBP (95% CI)* | P value | |
|---|---|---|---|---|
| NREM IFL | ||||
| Unadjusted model (n=1847) | −1.5 (−2.3 to −0.8) | <0.001 | −0.6 (−1.2 to 0.04) | 0.06 |
| Model 1 (n=1813) | −0.8 (−1.5 to −0.1) | 0.04 | −0.6 (−1.2 to 0.07) | 0.08 |
| Model 2 (n=1802) | −0.8 (−1.5 to −0.1) | 0.03 | −0.7 (−1.3 to −0.1) | 0.03 |
| Model 3 (n=1754) | −0.8 (−1.6 to −0.1) | 0.02 | −0.8 (−1.4 to −0.1) | 0.02 |
| REM IFL | ||||
| Unadjusted model (n=1811) | −0.9 (−1.7 to −0.2) | 0.02 | −0.1 (−0.7 to 0.5) | 0.76 |
| Model 1 (n=1778) | −0.3 (−1.0 to 0.4) | 0.41 | −0.2 (−0.8 to 0.5) | 0.60 |
| Model 2 (n=1767) | −0.3 (−1.0 to 0.4) | 0.36 | −0.2 (−0.8 to 0.4) | 0.50 |
| Model 3 (n=1713) | −0.2 (−0.9 to 0.6) | 0.60 | −0.1 (−0.7 to 0.6) | 0.78 |
Model 1: Adjusted for age, sex, race/ethnicity, body mass index (kg/m2), smoking status, cigarette pack-years, alcohol use, periodic limb movement, education level, % of time spent in N3 and N4 sleep.
Model 2: Model 1+hypoxic burden ((%·min)/hour).
Model 3: Model 2+ odds ratio product.
*
All results reported per SD increment of natural log-transformed NREM and REM IFL.
DBP, diastolic blood pressure; IFL, inspiratory flow limitation; NREM, non-rapid eye movement; REM, rapid eye movement;SBP, systolic blood pressure.