Figure 10.
Probiotic V and Met unaided or in combination regulate the lipid accumulation in the colon to prevent ethanol-induced intestinal injury. mRNA expression of lipogenic genes (a) AMPK, (b) SREBP-1c, (c) FAS, and (d) ACC involved in lipid metabolism in the rat colon and (e) levels of TC and (f) TG in the colon. The gene expression levels were measured after normalizing against 18S. Values are expressed as mean ± SD of six rats. Statistical analysis: one-way ANOVA followed by Tukey's post hoc test. ###p < 0.001 and ####p < 0.0001 compared to the control group; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001 compared with the ethanol-fed group; ap < 0.05 and aap < 0.01 compared with the E + probiotic V group; bp < 0.05, bbp < 0.01, and bbbp < 0.001 compared with the E + Met group.