Table 1.
Clinical and pathological characteristics of the study cohort categorized by age group
| Overall (n=119) | Age ≥80 (n=31) | Age <80 (n=88) | p | |
|---|---|---|---|---|
| Age at surgery, median (IQR) | 71 (66–79) | 82.5 (80–85) | 68.5 (65–72) | <0.01 |
| Gender, M:F | 93:26 | 23:8 | 70:18 | 0.61 |
| CCI, median (IQR) | 3 (2–4) | 3 (2–4) | ||
| CCI, n (%) | 0.82 | |||
| 0–3 | 86 (72%) | 22 (71%) | 64 (73%) | |
| 4+ | 33 (28%) | 9 (29%) | 24 (27%) | |
| Albumin, g/L, median (IQR) | 39 (35–42) | 38.5 (33–41) | 39 (36–42) | 0.12 |
| eGFR at presentation*, median (IQR) | 70 (56–88) | 64 (56–86) | 73 (58–88) | 0.43 |
| mFI, n (%) | 0.08 | |||
| 0 | 31 (26%) | 3 (10%) | 28 (32%) | |
| 1 | 32 (27%) | 11 (35%) | 21 (24%) | |
| 2 | 33 (28%) | 8 (26%) | 25 (28%) | |
| 3+ | 23 (19%) | 9 (29%) | 14 (16%) | |
| Clinical T stage, n (%) | 0.68 | |||
| T1 | 20 (17%) | 4 (13%) | 16 (18%) | |
| T2 | 63 (53%) | 18 (58%) | 45 (51%) | |
| T3 | 24 (20%) | 4 (13%) | 20 (23%) | |
| T4 | 7 (6%) | 2 (6%) | 5 (6%) | |
| Tx | 5 (4%) | 3 (10%) | 2 (2%) | |
| Clinical N stage, n (%) | 0.22 | |||
| N0 | 102 (86%) | 23 (74%) | 79 (90%) | |
| N+ | 12 (10%) | 5 (16%) | 7 (8%) | |
| Nx | 5 (4%) | 3 (10%) | 2 (2%) | |
| Neobladder, n (%) | 10 (8%) | 0 | 10 (11%) | 0.06 |
| Number LN removed, median (IQR) | 18 (12–25) | 16 (11–20) | 18 (12–26) | 0.30 |
| Positive surgical margins, n (%) | 9 (7%) | 4 (13%) | 5 (6%) | 0.20 |
| Pathological T stage, n (%) | 0.69 | |||
| T0 | 26 (22%) | 9 (29%) | 17 (19%) | |
| T1 | 9 (7%) | 1 (3%) | 8 (9%) | |
| T2 | 23 (19%) | 5 (16%) | 18 (20%) | |
| T3 | 41 (34%) | 10 (32%) | 31 (35%) | |
| T4 | 20 (17%) | 6 (19%) | 14 (16%) | |
| Pathological N stage, n (%) | 0.57 | |||
| N0 | 82 (69%) | 19 (61%) | 63 (72%) | |
| N1 | 12 (10%) | 3 (10%) | 9 (10%) | |
| N2 | 20 (17%) | 7 (23%) | 13 (15%) | |
| Nx | 5 (4%) | 2 (6%) | 3 (3%) | |
| eGFR after RC*, median (IQR) | 75 (54–91) | 68 (53–86) | 76 (54–100) | 0.14 |
*
Units of mL/min/1.73 m2.
CCI: Charlson comorbidity index; eGFR: estimated glomerular filtration rate; IQR: interquartile range; LN: Lymph nodes; mFI: modified frailty index; RC: radical cystectomy.