Table 3.
Differences in Lab Findings Among COVID-19 Patients without or with Different Kinds of Oxygen Therapy
| Variables | All (N=683) | No OT (N=315) | OT (N=300) | HFNOT or NIV (N=51) | IMV (N=17) | Pa |
|---|---|---|---|---|---|---|
| WBC | 4.8 (3.7–6.2) | 5.0 (3.9–6.3) ^ | 4.6 (3.6–6.0) ^ | 4.9 (4.1–6.0) ^ | 6.7 (4.4–9.1) *#& | 0.009 |
| Lym | 1.2 (0.8–1.7) | 1.3 (0.9–1.7) & | 1.2 (0.9–1.6) & | 0.8 (0.6–1.2) *# | 0.6 (0.4–0.9) | 0.02 |
| Neutrophil | 3.0 (2.3–4.1) | 3.1 (2.3–4.1) ^ | 2.9 (2.1–3.8) ^ | 3.6 (2.8–4.8) | 5.2 (4.2–7.8) *# | 0.03 |
| Platelets | 196 (148–249) | 219 (165–264) #&^ | 183 (143–240) *^ | 185 (144–213) *^ | 148 (124–165) *#& | <0.001 |
| Hb | 133 (123–145) | 135 (126–147) # | 130 (120–143) *& | 133 (124–152) #^ | 131 (116–136) & | 0.005 |
| PT | 12 (10–13) | 12 (11–13) # | 12 (11–13) * | 12 (11–13) | 12 (11–13) | 0.002 |
| APTT | 32 (29–36) | 32 (28–36) | 33 (30–36) | 32 (26–37) | 32 (26–38) | 0.44 |
| ALT | 21 (15–31) | 21 (15–36) # | 21 (15–28) *& | 28 (18–41) # | 23 (19–33) | 0.005 |
| AST | 24 (19–31) | 23 (18–31) & | 24 (19–31) & | 44 (86.3) *# | 29 (22–45) | 0.009 |
| Albumin | 40 (26–44) | 42 (39–45) &^ | 39 (36–42) | 35 (33–40) * | 33 (29–37) * | 0.04 |
| Globulin | 26 (23–29) | 25 (19–30) #&^ | 26 (23–28) *& | 29 (27–31) *# | 27 (26–32) * | <0.001 |
| CK | 68 (46–108) | 64 (45–98) &^ | 68 (46–106) &^ | 108 (54–195) *# | 168 (81–240) *# | <0.001 |
| Creatinine | 63 (51–76) | 65 (55–77) ^ | 58 (45–72) ^ | 65 (55–80) | 67 (55–87) *# | 0.01 |
| BUN | 4.1 (3.2–5.1) | 3.8 (3.1–4.6) & | 4.3 (3.2–5.3) & | 5.1 (3.8–8.1) *# | 6.5 (4.1–8.1) | <0.001 |
| LDH | 181 (147–224) | 180 (154–221) &^ | 171 (141–211) & | 241 (188–318) *# | 464 (305–511) | <0.001 |
| Lactate | 1.8 (1.2–2.6) | 1.6 (1.0–2.3) # | 2. 7 (1.9–3.1)* | 1.84 (1.25–2.71) | 2.20 (1.05–3.20) | 0.02 |
| PH | 7.5 (7.4–7.5) | 7.4 (7.4–7.5) | 7.5 (7.4–7.5) | 7.5 (7.4–7.5) | 7.5 (7.4–7.5) | 0.21 |
| PaCO2 | 36.7 (32.9–41.1) | 35.1 (28.7–37.7) | 37.5 (33.0–41.4) | 35.2 (29.6–38.7) | 33.8 (27–88.9) | 0.29 |
| PaO2 | 84.8 (72.4–94.6) | 94.1 (84.3–109)&^ | 83.4 (71.2–89.4) & | 67.2 (48.8–82)*#^ | 75 (54–97) * | <0.001 |
Notes: aP value for statistical difference among the four groups (No OT, OT, HFNOT or NIV, and IMV). *Means statistic difference with No OT group, #Means statistic difference with OT group, &Means statistic difference with HFNOT or NIV group, ^Means statistic difference with IMV group.
Abbreviations: COVID-19, coronavirus disease 2019; N, number of subjects; IQR, interquartile range; OT, oxygen therapy; HFNOT, High-flow nasal oxygen therapy; NIV, non-invasive ventilation; IMV, invasive mechanical ventilation; WBC, white blood cell; Lym, lymphocyte; Hb, hemoglobin; PT, Prothrombin Time; APTT, activated partial thromboplastin time; ALT; alanine aminotransferase; AST, aspartate aminotransferase; Ck, creatine kinase; BUN, blood urea nitrogen; LDH, Lactate dehydrogenase.