Table 1.

Summary of in vitro studies

Author (year)	ADSCs origin	Additional agents	Delivery	Route of delivery	Lymphangiogenesis or LE improvement	Paracrine action	Differentiation into LEC
Takeda et al. (2015) [20]	Animal	-	-	-	Yes	Yes	No
Strassburg et al. (2016) [17]	Human	VEGF-C	Culture media	-	Yes	Yes	No
Deng et al. (2017) [18]	Human	Prox-1	Virus	-	Yes	Yes	Yes
Saijo et al. (2019) [21]	Human	Irradiation	-	Yes	Yes	No
Sun et al. (2019) [19]	Human	IL-7	Culture media	-	Yes	Yes	Yes
Yan et al. (2011) [16]	Animal	VEGF-C	Culture media	Implanted Matrigel plug	Yes	Yes	Yes
		TGF-β1 inhibition	Virus

ADSCs, adipose-derived stem cells; LE, lymphedema; LEC, lymphatic endothelial cell; VEGF, vascular endothelial growth factor; Prox-1, prospero homeobox protein 1; IL, interleukin; TGF, transforming growth factor.