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. Author manuscript; available in PMC: 2022 Oct 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2021 Sep 14;60(42):22925–22932. doi: 10.1002/anie.202109714

Figure 8.

Figure 8.

Primer extension with three different terminal nucleotides. (A) The relative rates and structural parameters for the TNA and 3’-deoxyguanosine modifications as determined from the crystal structures. Each rate has been determined in triplicate. The C*C imidazolium bridged dinucleotide was used in the primer extension reactions. (B) Top-view of the superimposed RNA (gold) and TNA (cyan) structure showing the rotation of the TNA ring. The crystal structures have been deposited in the Protein Data Bank (PDB), with the following depository codes: TNA - 7LNG, 3-dG – 7LNF.