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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2021 Jun 17;156:106577. doi: 10.1016/j.prostaglandins.2021.106577

Fig. 6. Reduction of steatosis in chimeric mice bearing human hepatocytes by antagonism of LPAR1.

Fig. 6.

. cDNA-uPA/Scid mice with humanized livers were treated with control DMSO or AM095 every 3 days for a total of 3 times (male, n=3 for each group) and the livers were analyzed. (A) Oil red O staining of the liver tissues from the chimeric mice with AM095 or control DMSO. (B) Quantification of oil red O (ORO) staining. (C) Measurement of triglyceride levels (TG) in the livers. (D) CD36 mRNA expression of the liver tissues analyzed by QPCR. mRNA expression values were normalized against Gapdh. Each value is the mean ± SD of triplicate measurements. *, p < 0.05.