Table 5:
Associations between levels of chronic psychological stress and inflammatory biomarkers. Multi-Ethnic Study of Atherosclerosis: Ancillary Study of Body Composition and Adiposity-Related Inflammation (Exam 2/3), United States
| lnIL6 | lnLeptin | Resistin | lnTNF-alpha | lnCRP | lnAdiponectin | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta (SE) | P-Val | Beta (SE) | P-Val | Beta (SE) | P-Val | Beta (SE) | P-Val | Beta (SE) | P | Beta (SE) | P | |
| Full Sample | ||||||||||||
| Chronic Stress | ||||||||||||
| Low (0) | ref | 0.20 | Ref | 0.10 | ref | 0.73 | ref | 0.90 | ref | 0.81 | ref | 0.93 |
| Med (1) | −0.01 (0.03) | 0.06 (0.05) | 0.02 (0.02) | 0.01 (0.03) | −0.02 (0.06) | 0.01 (0.03) | ||||||
| High (2+) | 0.06 (0.04) | 0.12 (0.06) | 0.01 (0.02) | −0.01 (0.03) | −0.04 (0.06) | 0.002 (0.03) | ||||||
| Stratified by study visit | ||||||||||||
| Exam 2 (n= 704) | ||||||||||||
| Low (0) | ref | 0.60 | ref | 0.38 | ref | 0.28 | ref | 0.09 | ref | 0.20 | ref | 0.23 |
| Med (1) | 0.03 (0.05) | 0.10 (0.08) | 0.06 (0.04) | 0.01 (0.05) | −0.06 (0.09) | 0.06 (0.05) | ||||||
| High (2+) | −0.03 (0.06) | −0.03 (0.09) | 0.03 (0.04) | −0.11 (0.05) | −0.18 (0.10) | 0.08 (0.05) | ||||||
| Exam 3 (n= 1077) | ||||||||||||
| Low (0) | ref | 0.01 | ref | 0.02 | ref | 0.96 | ref | 0.42 | ref | 0.84 | ref | 0.51 |
| Med (1) | −0.03 (0.04) | 0.04 (0.07) | −0.01 (0.03) | 0.005 (0.04) | −0.003 (0.08) | −0.02 (0.04) | ||||||
| High (2+) | 0.12 (0.05) | 0.21 (0.07) | −0.01 (0.03) | 0.05 (0.04) | 0.04 (0.08) | −0.05 (0.04) | ||||||
| P-Interactiona | 0.08 | 0.11 | 0.75 | 0.03 | 0.20 | 0.41 | ||||||
| Stratified by sex | ||||||||||||
| Women | ||||||||||||
| Low (0) | ref | 0.05 | Ref | 0.41 | Ref | 0.74 | ref | 0.88 | ref | 0.35 | ref | 0.28 |
| Med (1) | −0.07 (0.05) | 0.03 (0.07) | −0.01 (0.04) | 0.01 (0.03) | −0.10 (0.09) | −0.03 (0.04) | ||||||
| High (2+) | 0.07 (0.05) | 0.09 (0.07) | −0.03 (0.05) | −0.004 (0.03) | 0.03 (0.09) | −0.07 (0.04) | ||||||
| Men | ||||||||||||
| Low (0) | ref | 0.34 | Ref | 0.16 | Ref | 0.88 | ref | 0.64 | ref | 0.12 | ref | 0.18 |
| Med (1) | 0.07 (0.05) | 0.11 (0.08) | 0.02 (0.04) | 0.02 (0.03) | 0.07 (0.08) | 0.04 (0.04) | ||||||
| High (2+) | 0.04 (0.05) | 0.16 (0.09) | 0.02 (0.05) | 0.03 (0.04) | −0.13 (0.09) | 0.09 (0.05) | ||||||
| P-Interactionb | 0.04 | 0.47 | 0.84 | 0.78 | 0.06 | 0.18 | ||||||
Models adjust for age, sex, race, education, height, smoking status (yes/no), pack years smoked, physical activity and sedentary behaviors
a
p-value for interaction between chronic stress * time between baseline exam and inflammatory biomarker data collection
b
p-value for interaction between chronic stress * sex