Table 1.

Survey of papers that reported cancer cell responses (proliferation, migration and apoptosis) to solid compressive stress or hydrostatic pressure. Model systems used, magnitude of stress and time of stress application are also included.

Cancer Cell type	Type of model		Mechanical Stress		Stress parameters		Effect on			Ref.
	2D In vitro culture	3D culture	Solid compressive stress	Hydrostatic pressure	Magnitude (mm Hg)	Duration	Proliferation	Migration	Apoptosis
H4 Brain tumor		✓	✓		60	21 d	↓			(Kalli, Voutouri, et al., 2019)
A172 Brain tumor		✓	✓		26	21 d	↓			(Kalli, Voutouri, et al., 2019)
MDA-MB 231 Breast cancer		✓	✓			6 d		↑		(Chun Liu, Lewin Mejia, Chiang, Luker, & Luker, 2018)
HCT116 Colorectal cancer		✓	✓				↓		No change	(Desmaison et al., 2013)
HT29 Human colon carcinoma		✓	✓		35 –75		↓		No change	(Delarue et al., 2014)
CT26 Mouse colon adenocarcinoma		✓	✓		35 –75		↓			(Delarue et al., 2014)
BC52 Human breast cancer		✓	✓		35 –75		↓			(Delarue et al., 2014)
AB6 Mouse sarcoma		✓	✓		35 –75		↓			(Delarue et al., 2014)
LS174T Human colon adenocarcinoma		✓	✓		45 –120	30 d	No change		↓	(Helmlinger et al., 1997)
4T1, 67NR, MDA-MB 231 Breast cancer	✓		✓		5.8	16 h		↑		(Janet M. Tse et al., 2012)
MCF 10A, MCF7 Breast cancer	✓		✓		5.8	16 h		↓		(Janet M. Tse et al., 2012)
67NR Breast cancer	✓		✓		> 5.8 –58	16 h		↓	↑	(Cheng et al., 2009; Janet M. Tse et al., 2012)
H4 Brain tumor (Glioma)	✓		✓		4	16 h		↑		(Kalli, Voutouri, et al., 2019)
A172 Brain tumor	✓		✓		4	16 h		No change		(Kalli, Voutouri, et al., 2019)
CFPAC-1 (Pancreatic cancer)	✓		✓		1–6	6 h		↑		(Kalli et al., 2018)
PaCa-2/BxPC-3 (Pancreatic cancer)	✓		✓		4	16 h		↑		(Kalli, Minia, et al., 2019)
hTRET-AM Ameloblastoma epithelial cells	✓			✓	30 –90		↓	↑		(Yang et al., 2018)
CL1–5 & A549 Lung cancer cells	✓			✓	0 –20	8 h	↑	↑		(Y. Kao, C. Lee, & P. Kuo, 2014; Kao et al., 2017)
SCC-4/SCC-9 Oral squamous carcinoma	✓			✓	0 –30	24 h	↑	↑		(T. Yu et al., 2013)
U2OS Osteosarcoma	✓			✓	0 –50	72 h	↑		↓	(DiResta et al., 2005; Nathan et al., 2005)
SaOS2 Osteosarcoma	✓			✓	0 –50	72 h	↓			(DiResta et al., 2005)
HOS Osteosarcoma	✓			✓	0 –100	72 h	↓		↑	(DiResta et al., 2005; Nathan et al., 2005)
MCF7 Breast cancer	✓			✓	0–100	72 h	↓			(DiResta et al., 2005)
H1299 Lung carcinoma	✓			✓	0–100	72 h	↓			(DiResta et al., 2005)
A431/A 549 Epithelial tumor		In vivo		✓	10/5		↑			(Hofmann et al., 2006)