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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Immunol Cell Biol. 2021 Jun 28;99(9):936–948. doi: 10.1111/imcb.12486

Figure 3.

Figure 3.

A decision tree model of functional recognition governs Type 2 immunity. Because functional recognition underlies both antigen-independent wound healing and antigen-specific Type 2 immunity, innate immune cells must discriminate when to mount each response. The decision tree model of functional recognition proposes that alone, DAMPs initiate tissue repair pathways. Only when in combination with a NAMP can DAMPs instruct innate immune cells to generate antigen-specific Type 2 immunity. Thus, antigen-specific Type 2 immune responses are guarded by an extra layer of signaling that is required to generate antigen specificity. This decision tree model explains how functional recognition can govern such disparate immune responses.