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. 2021 Oct 4;11:19616. doi: 10.1038/s41598-021-98611-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Intestinal macrophages in health and disease. (A) Proportion of total macrophages (CD64 + HLA-DR +) inthe lamina propria of healthy colonic tissue, and tissue isolated from CD and UC patients. (B) Ratio of CD206⁻:CD206 + macrophages. UCr UC tissue in remission, UCa active (inflamed) UC tissue, CDn CD tissue in remission and CDd active (inflamed) CD tissue. Sample numbers are n = 18, 8, 8, 9 and 10 for Healthy, UCr, UCa, CDr and CDa, respectively.