Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 4;12:5812. doi: 10.1038/s41467-021-26100-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Thermal sensitivity of animals in the CFA pain model with a pre-inflammatory knockdown paradigm for scrambled (n = 11) and AP2α2 (n = 12) shRNA groups. Data is pooled males and females and is represented as mean paw withdrawal latency (PWL) ± S.E.M. Significance determined using repeated measures 2-way ANOVA with Bonferroni correction p < 0.05; *p < 0.01; ** Day 8: Ipsilateral Scrambled shRNA vs Ipsilateral AP2α2 shRNA p-value = 0.0398. Day 12: Ipsilateral scrambled shRNA vs Ipsilateral AP2α2 shRNA p-value = 0.0048. Day 16: Ipsilateral scrambled shRNA vs ipsilateral AP2α2 shRNA p-value = 0.0013. b von Frey withdrawal threshold of ipsilateral hind paw in a chronic inflammatory pain model where knockdown occurred before inflammation was initiated. Data for the scrambled (n = 8) and AP2α2 (n = 8) shRNA groups is pooled, males and females, and is represented as mean percentage of baseline ± S.E.M. Significance determined using repeated measures 2-way ANOVA with Bonferroni correction p < 0.05; *. Day 13: Scrambled shRNA vs AP2α2 shRNA p-value = 0.0315. Contralateral PWT can be found in Supplementary Fig. 2. c Thermal sensitivity of animals injected with scrambled (n = 8) and AP2α2 (n = 8) shRNAs following establishment of inflammation. Data is pooled males and females and is represented as mean PWL ± S.E.M. Significance determined using repeated measures 2-way ANOVA with Bonferroni correction p < 0.05; *p < 0.01; **. Day 9: Ipsilateral scrambled shRNA vs ipsilateral AP2α2 shRNA p-value = 0.0251. Day 13: Ipsilateral scrambled shRNA vs Ipsilateral AP2α2 shRNA p-value = 0.0064.