Table 2.
Canonical signaling pathways are shown.
| Ingenuity canonical pathways | −log(P value) | z score |
|---|---|---|
| EIF2 signaling | 9.4 | 1.265 |
| Relaxin signaling | 3.39 | 1.342 |
| ERK/MAPK signaling | 2.68 | 0.707 |
| BMP signaling pathway | 2.28 | 0.447 |
| PPARα/RXRα activation | 1.37 | 1.633 |
| TGF-β signaling | 2.76 | −0.447 |
| Acute-phase response signaling | 2.53 | −0.816 |
| SPINK1 pancreatic cancer pathway | 2.04 | −2 |
| PPAR signaling | 1.91 | −0.447 |
| Glioma invasiveness signaling | 1.66 | −1 |
The canonical signaling pathways were analyzed using IPA software based on the results of differentially expressed genes. ten was the base of −log(P value). −Log(P = 0.05) = 1.3, Therefore, the statistical significance was −log(P value)>1.3. z score >0 represented this signaling pathway was activated in the research; z score <0 represented this signaling pathway was inhibited in this experiment. The more scores the signaling pathway got in the study, the more obvious the statistical difference was. The results provided us potential materials to investigate the relationship between LHPP biological functions and classical signaling pathways.