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. 2021 Sep 3;11(19):9180–9197. doi: 10.7150/thno.60503

Figure 2.

Figure 2

High expression levels of BCL2L1, CDK1, CDK6, and WEE1 correlate with lower survival rate of TNBC patients. (A-C) Analysis of publicly available microarray data from 580 TNBC patients (GSE31519 Affymetrix Human Genome U133A Array). Kaplan-Meier curves reporting the probability of the overall survival of human TNBC patients according to the expression levels of the BCL2L1 gene, encoding BCL-XL (A), specific cell cycle regulators (CDK1, CDK2, CDK4, CDK6, WEE1, FOXM1, AURKA, and AURKB) alone (B) or in combination with BCL2L1 (C). In these combinations (C), the expression levels indicated correspond to those of the cell cycle regulators and BCL2L1, respectively. The median of each gene expression levels was used as a threshold to segregate high versus low expressers. P values were computed using the Logrank (Mantel Cox) test. (D,E) Tumour grades reported in patients with high or low levels of either single (D) or combined (E) indicated genes. Tumour grades were defined according to standard pathological scores (1-3; 3 corresponds to the most aggressive grade). Note that the BCL2L1 gene codes for BCL-XL, and that the AURKA and the AURKB genes encode the Aurora Kinase A and the Aurora Kinase B, respectively. ns: not significant; * P < 0.05; ** P < 0.01; *** P < 0.001.