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. 2021 Sep 3;11(19):9180–9197. doi: 10.7150/thno.60503

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Combined A1155463 + R547 treatment interferes with tumour growth in orthotopic grafts. (A) Scheme illustrating orthotopic injection of MDA-MB-231 cells in the mammary fat pad of nude mice, frequency of drugs administration, mouse weight and tumour volume measurement. (B-D) Effects of A1155463 + R547 treatment on tumour growth. (B) Evolution of tumour volume during the whole experiment. (C-D) Graphs reporting tumour volume (C) and tumour weight (D) at the end point of the experiment (day 31). (E) Graph showing the evolution of the body weight of mice during the whole procedure. No significant changes were observed, indicating that the dose of drugs used in vivo were not toxic. A11: A1155463. Values are expressed as the mean ± s.e.m. For B: two-way ANOVA statistical analysis was performed. For C and D: unpaired Student's t test was used. ns: not significant; * P < 0.05; ** P < 0.01; *** P < 0.001.