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. 2021 Sep 3;11(19):9243–9261. doi: 10.7150/thno.63354

Figure 7.

Figure 7

Lack of the TF cytoplasmic domain promotes angiogenesis in infarcted myocardium. (A) Representative images of infarcted heart sections stained with DAPI (blue), WGA (green) and IB4 (red) at 7 days post-MI. (B and C) Quantification of blood vessel density and PAR2 staining in the infarct-and-border region. N = 5 - 7 per genotype per time-point; Mann-Whitney U test, *p < 0.05, **p < 0.01 compared with WT mice. (D) A representative heart section of a TF∆CT mouse at 28 days post-MI demonstrating co-localization of PAR2 with myocardial capillaries (stained with IB4). Panels (D', D'') show close-up of infarct border and infarct regions, respectively. An inset (D''') shows close-up of myocardial capillaries in the infarct region. White arrowheads indicate co-localization of PAR2 with capillaries. Scale bars: 100 µM.