Table 1.
Echocardiography characterization
| WT | TF∆CT | |||||
|---|---|---|---|---|---|---|
| Baseline | 7 days MI | 28 days MI | Baseline | 7 days MI | 28 days MI | |
| HR (bpm) | 397.9 ± 7.0 | 444.7 ± 12.2‡ | 428.2 ± 14.9 | 391.5 ± 9 | 444.5 ± 21.2 | 385.6 ± 8.6§ |
| ESV (μl) | 31.92 ± 1.7 | 95.10 ± 11.5‡ | 114.5 ± 13.1‡ | 28.32 ± 1.5 | 66.91 ± 13.97* | 67.06 ± 10.8†# |
| EDV (μl) | 65.51 ± 2.6 | 124.7 ± 10.9‡ | 146.6 ± 12.4‡ | 61.01 ± 2.1 | 94.35 ± 13.4*§ | 99.97 ± 11.71†# |
| EF (%) | 51.25 ± 1.5 | 27.4 ± 2.9‡ | 24.69 ± 2.5‡ | 53.88 ± 1.2 | 33.00 ± 3.413‡ | 35.91 ± 1.93‡# |
| FS (%) | 26.11 ± 1.0 | 11.37 ± 1.3‡ | 10.44 ± 1.2‡ | 28.69 ± 1.5 | 12.63 ± 1.7‡ | 13.03 ± 1.3‡ |
| LVIDs (mm) | 3.086 ± 0.08 | 4.609 ± 0.24‡ | 5.072 ± 0.24‡ | 2.875 ± 0.1 | 4.265 ± 0.31‡ | 4.326 ± 0.25‡§ |
| LVIDd (mm) | 4.158 ± 0.06 | 5.158 ± 0.19‡ | 5.622 ± 0.2‡ | 4.011 ± 0.07 | 4.846 ± 0.26‡ | 4.938 ± 0.21‡# |
Echocardiography was performed on the mice at baseline (before MI) and at the indicated time after MI. Paired t-test compared to respective baseline: *p < 0.05, †p < 0.01, ‡p < 0.001; Mann-Whitney U test compared to WT: §p < 0.05, #p < 0.001. N = 19 for WT mice and n = 19 for TF∆CT mice. HR, heart rate (beat per minute); ESV, end systolic volume; EDV, end diastolic volume; EF, ejection fraction; FS, fractional shortening; LVIDs, left ventricular internal diameter end systole; LVIDd, left ventricular internal diameter end diastole.