Figure 2.

Lysyl hydroxylase 1 (LH1) deficiency increases structural damage to the aorta in response to angiotensin II (Ang II) administration. A, Representative cross-sections of hematoxylin and eosin (H&E)-, Verhoeff-Van Gieson (VVG)-, Masson trichrome- and picrosirius red (PSR)-stained abdominal aorta tissues from mice after 4 weeks of Ang II or saline infusion. Quantification of elastin breakage (VVG staining, B) and collagen content (PSR staining, C) (n = 6). D, Transmission electron microscopy images showing an overview, collagen fibers, and cross-sectioned fibers in the abdominal aortas of mice. Two-way ANOVA followed by Bonferroni post hoc test.