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Proposed mechanisms of NmbR signalling on Cav3.2 channels in TG neurons. The binding of Nmb triggers NmbR to activate Gq protein and releases the Gβγ subunits. The released Gβγ dimer then stimulates AMPK activity, induces the activation of PKA and subsequently phosphorylates Cav3.2 channels to increase IT. Neither PLC/PKC nor direct binding of Gβγ to Cav3.2 channels is required for T-type channel response mediated by NmbR.
