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. 2021 Sep 21;11(19):9571–9586. doi: 10.7150/thno.61711

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Plk1 is overexpressed in HNSCC patients and is associated with a poor prognosis. The tumors of HNSCC patients were analyzed for Plk1 mRNA levels (z-score). These results are in whole based upon data generated by the TCGA Research Network. (A) Comparison of Plk1 mRNA levels in several cancer. (B) Comparison of Plk1 mRNA levels between healthy (n = 44) and HNSCC tissues (n = 519). (C-D) The levels of Plk1 mRNA in tumors of HNSCC patients correlated with DFS (C) and OS (D). (E-F) The levels of Plk1 mRNA in patients' tumors from Centre Antoine Lacassagne correlated with DFS (E) and OS (F). DFS and OS were calculated from patient subgroups with mRNA levels that were less or greater than the third quartile value. Statistical significance (p value) is indicated. (G) Plk1 mRNA measured by qPCR in tumors from Centre Antoine Lacassagne's patients at diagnosis and after relapse to usual treatments (n = 20).