Fig. 1.
Effects of blocking ASIC2 on aortic arch baroreceptor discharges. A Baroreceptor discharges recorded in rat aortic arch nerve preparations under pulsatile pressure before (control group) and after perfusion of 100 µmol/L amiloride, and after removal of the amiloride by washing with perfusate (wash group). B Statistical analysis of the effect of 100 μmol/L amiloride (n = 5; ***P <0.001 vs control group). C Baroreceptor discharges recorded before (control group) and after perfusion with different concentrations of benzamil, and after removal of benzamil by washing with perfusate (wash group). D Statistical analysis of the effect of benzamil (n = 3; ***P <0.001 vs control group, ###P <0.001 vs wash group; binwidth, 0.05 s). E Expansion of the boxed area in (C). ANA, aortic nerve activity; IAP, intravascular aortic pressure. 1 mmHg = 0.133 kPa.