The first-trimester changes in thyroid parameters of women undergoing COH. COH, controlled ovarian hyperstimulation; OI, ovulation induction (the end of COH); ET, embryo transplantation; PT, pregnancy tests; and TSH, thyroid-stimulating hormone. The bold lines indicate the pooled changes. The light blue lines indicate changes in each study. The three red points represent the beginning of COH, the end of COH, and the pregnancy test