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. 2021 Jul 26;37(10):1427–1440. doi: 10.1007/s12264-021-00750-4

Fig. 5.

Fig. 5

Decreased circRad52 after epilepsy is involved in the regulation of TRPV1 by C3. A, C Quantitative RT-PCR measurement of circRad52 knockdown (A) and overexpression efficiency (C) in the Neuro-2a cell line. B, D Quantitative RT-PCR measurement of TRPV1 RNA expression under circRad52 knockdown and overexpression in C3-treated Neuro-2a cells. E Representative images of TRPV1 and MAP2 in mouse brain sections with knockdown of circRad52. F The statistical graph of E. G, I Representative images of Nissl-stained brain sections from circRad52 mice and statistical summary. J Representative images of SYN and MAP2 in brain sections from mice with knockdown of circRad52. H The statistical graph of J. K, L Example trajectories and statistics for the water maze test after overexpression and knockdown of circRad52 (NE, northeast; NW, northwest; SE, southeast; SW, southwest; target quadrant: SW). *P <0.05, **P <0.01, ***P <0.001; ns, not significant.