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The mechanism of complement C3 aggravation of neuronal injury. After epilepsy, activated astrocytes secrete a large amount of C3 to act on neuronal C3aR, resulting in the down-regulation of circRad52, which in turn promotes the up-regulation of neuronal TRPV1. The abnormal expression of TRPV1 in neurons impairs their physiological function and promotes damage. Taken together, C3 promotes neuronal injury through the C3–circRad52–TRPV1 pathway after epilepsy.
