Table 1.
Baseline characteristics of study participants.
| Total (n = 30) | Relapsing (n = 17) | Non-relapsing (n = 13) | P-value | |
|---|---|---|---|---|
| Demographics | ||||
| Age (yrs) | 11.6 ± 6.9 | 11.1 ± 6.7 | 12.3 ± 7.4 | 0.65 |
| Sex n (%) | 0.24 | |||
| Female | 6 (20) | 2 (12) | 4 (31) | |
| Male | 24 (80) | 15 (88) | 9 (69) | |
| Treatment | 0.29 | |||
| Rituximab n (%) | 15 (50) | 10 (59) | 5 (38) | |
| Ofatumumab n (%) | 15 (50) | 7 (41) | 8 (62) | |
| Prior rituximab use, n (%) | 12 (40) | 6 (35) | 6 (46) | 0.36 |
| Number of prior relapses, n | 1.5 (1-10) | 2 (1-10) | 1 (1-6) | 0.52 |
| Immunosuppressive drugs at enrollment (T0), n (%) | ||||
| Steroids | 30 (100) | 17 (100) | 13 (100) | 1.0 |
| Tac | 16 (53) | 9 (53) | 7 (58) | 0.96 |
| CsA | 13 (43) | 8 (47) | 5 (38) | 0.63 |
| Labs | ||||
| Serum Creatinine (mg/dL) | 0.54 ± 0.24 | 0.53 ± 0.27 | 0.55 ± 0.20 | 0.85 |
| Serum Albumin (g/dL) | 3.73 ± 0.64 | 3.74 ± 0.55 | 3.71 ± 0.77 | 0.88 |
| Cholesterol (mg/dL) | 210 ± 61 | 192 ± 57 | 232 ± 61 | 0.09 |
| eGFR (ml/min) | 137 ± 38 | 142 ± 39 | 129 ± 37 | 0.35 |
| IgA (mg/dL) | 658 ± 231 | 638 ± 243 | 685 ± 221 | 0.59 |
| IgM (g/dL) | 166 ± 109 | 162 ± 127 | 171 ± 84 | 0.82 |
| IgG (mg/dL) | 144 ± 83 | 150 ± 99 | 134 ± 60 | 0.60 |
| Proteinuria (mg/24 h) | 99 ± 83 | 116 ± 104 | 78 ± 36 | 0.18 |
Data are mean ± SD number (%), or median (range). p-value compares the two treatment groups in a two-tailed t-test of heteroscedastic variance or chi squared. Tac, tacrolimus; CsA, cyclosporine.