Table 4.

Accuracy of different strategy in screening patients with HSIL.

	HSIL (cases)		PPV (%)
Screening method	Yes	No
HPV 16 and/or 18 positive
Met	48	15	76.19
HPV 16 and/or 18 positive plus vaginal microbiome
Met	52	11	82.54
Incident infection of HPV other 12 types with abnormal TCT result *
Met	16	24	40.00
Incident infection of HPV other 12 types with abnormal TCT result plus vaginal microbiome
Met	27	13	67.50

^*Normal TCT result is defined as “no intraepithelial lesions or malignant cells (NILM)”, while abnormal TCT result includes “atypical squamous cells of unknown significance (ASCUS)”, “lower-grade squamous intraepithelial lesions (LSIL)”, “high-grade squamous intraepithelial lesions (HSIL)”, and ”atypical squamous cells: cannot exclude high-grade squamous intraepithelial lesions (ASC-H)”.

HPV, human papillomavirus; NPV, negative predictive value; PPV, positive predictive value; Sen., sensitivity; Spe., specificity; TCT, ThinPrep cytology test.