Table 2.
Tumor proximity to selected ROI—Comparison by choice of surgical strategy//Sensitivity analysis with overlap threshold 10 mm3.
| Population-based (N=277) | Biopsy (N=55) | Resection (N=222) | P value1 | Univariable logistic regression | Sensitivity analysis | ||||
|---|---|---|---|---|---|---|---|---|---|
| Response: Only biopsy | //Biopsy (N=55) | //Resection (N=222) | //P value1 | ||||||
| 95% Wald CI | P value2 | ||||||||
| Any voxel-based eloquent region, No (%) | 232 (83.8) | – | – | – | 0.400, 3.301 | 0.012 | – | – | – |
| Cortical and subcortical parcellation atlas, No (%) | |||||||||
| Precentral cortex left | 88 (31.8) | 26 (47.3) | 62 (27.9) | 0.009 | 0.234, 1.444 | 0.007 | 26 (47.3) | 59 (26.6) | 0.005 |
| Precentral cortex right | 73 (26.4) | 18 (32.7) | 55 (24.8) | 0.236 | -0.250, 1.030 | 0.232 | 18 (32.7) | 52 (23.4) | 0.168 |
| Postcentral cortex left | 69 (24.9) | 24 (43.6) | 45 (20.3) | <0.001 | 0.488, 1.739 | <0.001 | 24 (43.6) | 43 (19.4) | <0.001 |
| Postcentral cortex right | 54 (19.5) | 16 (29.1) | 38 (17.1) | 0.057 | 0.008, 1.365 | 0.047 | 16 (29.1) | 35 (15.8) | 0.032 |
| Pericalcarine left | 17 (6.1) | 10 (18.2) | 7 (3.2) | <0.001 | 0.903, 2.939 | <0.001 | 10 (18.2) | 6 (2.7) | <0.001 |
| Pericalcarine right | 14 (5.1) | 5 (9.1) | 9 (4.1) | 0.163 | -0.274, 1.997 | 0.137 | 4 (7.3) | 5 (2.3) | 0.080 |
| Hippocampus left | 69 (24.9) | 28 (50.9) | 41 (18.5) | <0.001 | 0.893, 2.149 | <0.001 | 27 (49.1) | 38 (17.1) | <0.001 |
| Hippocampus right | 47 (17.0) | 14 (25.5) | 33 (14.9) | 0.072 | -0.040, 1.381 | 0.064 | 13 (23.6) | 33 (14.9) | 0.155 |
| Para hippocampal area left | 44 (15.9) | 19 (34.5) | 25 (11.3) | <0.001 | 0.731, 2.120 | <0.001 | 17 (30.9) | 22 (9.9) | <0.001 |
| Para hippocampal area right | 35 (12.6) | 12 (21.8) | 23 (10.4) | 0.038 | 0.110, 1.653 | 0.025 | 12 (21.8) | 20 (9.0) | 0.016 |
| Supramarginal left | 49 (17.7) | 23 (41.8) | 26 (11.7) | <0.001 | 1.016, 2.364 | <0.001 | 23 (41.8) | 24 (10.8) | <0.001 |
| Pars Triangularis left | 71 (25.6) | 20 (36.4) | 51 (23.0) | 0.057 | 0.018, 1.282 | 0.044 | 18 (32.7) | 48 (21.6) | 0.110 |
| Pars Opercularis left | 87 (31.4) | 24 (43.6) | 63 (28.4) | 0.035 | 0.062, 1.277 | 0.031 | 24 (43.6) | 59 (26.6) | 0.021 |
| Inferior parietal left | 31 (11.2) | 17 (30.9) | 14 (6.3) | <0.001 | 1.107, 2.681 | <0.001 | 16 (29.1) | 12 (5.4) | <0.001 |
| Atlas of reconstructed white mater tracs, No (%) | |||||||||
| CS left | 108 (39.0) | 35 (63.6) | 73 (32.9) | <0.001 | 0.656, 1.890 | <0.001 | 34 (61.8) | 68 (30.6) | <0.001 |
| CS right | 95 (34.3) | 28 (50.9) | 67 (30.2) | 0.007 | 0.274, 1.476 | 0.004 | 26 (47.3) | 63 (28.4) | 0.010 |
| OR left | 70 (25.3) | 30 (54.5) | 40 (18.0) | <0.001 | 1.066, 2.329 | <0.001 | 27 (49.1) | 32 (14.4) | <0.001 |
| OR right | 59 (21.3) | 15 (27.3) | 44 (19.8) | 0.269 | -0.262, 1.096 | 0.229 | 12 (21.8) | 39 (17.6) | 0.444 |
| IFOF left | 107 (38.6) | 31 (56.4) | 76 (34.2) | 0.003 | 0.308, 1.510 | 0.003 | 31 (56.4) | 74 (33.3) | 0.003 |
| SLF left | 75 (27.1) | 31 (56.4) | 44 (19.8) | <0.001 | 1.027, 2.280 | <0.001 | 31 (56.4) | 42 (18.9) | <0.001 |
| AF left | 82 (29.6) | 32 (58.2) | 50 (22.5) | <0.001 | 0.944, 2.187 | <0.001 | 32 (58.2) | 46 (20.7) | <0.001 |
1 Fisher’s exact test was used for comparison between biopsy and resection groups. 2 Univariable logistic regression was used with choice of primary surgical strategy as response variable. Bold values indicate significant P value < 0.002.