Table 4.
Details on voxel-based eloquence and comparative results by molecular subgroups according to WHO 2016.
| Cases with complete molecular data (N=222) | IDH-wt astrocytoma (N=82) | IDH-mut astrocytoma (N=67) | Oligodendroglioma (N=73) | P value1 | |
|---|---|---|---|---|---|
| Clinical variables, | |||||
| Age at surgery, mean (95% CI) | 46.4 (44.4, 48.3) | 52.0 (48.7, 55.3) | 40.3 (37.1, 43.4) | 45.6 (42.5, 48.7) | <0.001 |
| KPS2 at admission, median (Q1, Q3) | 90 (80, 90) | 90 (70, 90) | 90 (80, 90) | 90 (80, 100) | 0.008 |
| KPS (<90), No (%) | 83 (37.4) | 40 (48.8) | 22 (32.8) | 21 (28.8) | 0.026 |
| Tumor volume3 in ml, median (Q1, Q3) | 56.9 (27.5, 108.8) | 55.1 (19.9, 97.2) | 77.9 (32.9, 137.0) | 54.2 (28.8, 110.0) | 0.185 |
| Presumed eloquence, No (%) | 151 (68.0) | 62 (75.6) | 46 (68.7) | 43 (58.9) | 0.084 |
| Any voxel-based eloquent region, No (%) | 185 (83.3) | 77 (93.9) | 54 (80.6) | 54 (74.0) | 0.002 |
| Only biopsy, No (%) | 49 (22.1) | 35 (42.7) | 8 (11.9) | 6 (8.2) | <0.001 |
| Cortical and subcortical parcellation atlas, No (%) | |||||
| Precentral cortex left | 71 (32.0) | 29 (35.4) | 26 (38.8) | 16 (21.9) | 0.071 |
| Precentral cortex right | 56 (25.2) | 21 (25.6) | 14 (20.9) | 21 (28.8) | 0.577 |
| Postcentral cortex left | 57 (25.7) | 28 (34.1) | 18 (26.9) | 11 (15.1) | 0.022 |
| Postcentral cortex right | 44 (19.8) | 17 (20.7) | 12 (17.9) | 15 (20.5) | 0.911 |
| Pericalcarine left | 14 (6.3) | 8 (9.8) | 4 (6.0) | 2 (2.7) | 0.205 |
| Pericalcarine right | 12 (5.4) | 5 (6.1) | 5 (7.5) | 2 (2.7) | 0.427 |
| Hippocampus left | 60 (27.0) | 37 (45.1) | 16 (23.9) | 7 (9.6) | <0.001 |
| Hippocampus right | 41 (18.5) | 22 (26.8) | 11 (16.4) | 8 (11.0) | 0.036 |
| Parahippocampal area left | 37 (16.7) | 26 (31.7) | 10 (14.9) | 1 (1.4) | <0.001 |
| Parahippocampal area right | 32 (14.4) | 18 (22.0) | 10 (14.9) | 4 (5.5) | 0.010 |
| Supramarginal left | 43 (19.4) | 23 (28.0) | 15 (22.4) | 5 (6.8) | 0.002 |
| Pars Triangularis left | 57 (25.7) | 20 (24.4) | 18 (26.9) | 19 (26.0) | 0.944 |
| Pars Opercularis left | 70 (31.5) | 25 (30.5) | 26 (38.8) | 19 (26.0) | 0.261 |
| Inferior parietal left | 25 (11.3) | 13 (15.9) | 10 (14.9) | 2 (2.7) | 0.010 |
| Atlas of reconstructed white mater tracs, No (%) | |||||
| CS left | 92 (41.2) | 40 (48.8) | 32 (47.8) | 20 (27.4) | 0.012 |
| CS right | 79 (35.6) | 37 (45.1) | 17 (25.4) | 25 (34.2) | 0.042 |
| OR left | 59 (26.6) | 35 (42.7) | 17 (25.4) | 7 (9.6) | <0.001 |
| OR right | 49 (22.1) | 23 (28.0) | 15 (22.4) | 11 (15.1) | 0.148 |
| IFOF left | 90 (40.5) | 40 (48.8) | 25 (37.3) | 25 (34.2) | 0.152 |
| SLF left | 63 (28.4) | 31 (37.8) | 21 (31.3) | 11 (15.1) | 0.005 |
| AF left | 70 (31.5) | 35 (42.7) | 23 (34.3) | 12 (16.4) | 0.001 |
1One-way ANOVA, Kruskal–Wallis, or Fisher–Freeman–Halton exact tests were used when appropriate for three-group comparison between oligodendroglioma, IDH-mutated astrocytoma (IDH-mut astrocytoma), and IDH wild-type astrocytoma (IDH-wt astrocytoma). 2 Karnofsky performance status. 3 Tumor volumes computed after registration to MNI space. Reported in milliliters for convenience. Bold values indicate significant P value < 0.002.